BURBANK, CA - AUGUST 29: Executive producer Oprah Winfrey attends OWN: Oprah Winfrey Network's “Queen Sugar” premiere at the Warner Bros. Studio Lot Steven J. Ross Theater on August 29, 2016 in Burbank, California. (Photo by Mike Windle/Getty Images)

We can see this happening! 

With J-Lo as Secretary of State and Dwayne Johnson as Secretary of Defense, Oprah is set to go. Check out this hilarious lineup.

E! Picks Oprah Winfrey's Presidential Cabinet Members | E! News

The "A Wrinkle in Time" actress is pegged by fans to run in the 2020 presidential race. E! selects which stars should hold positions in Oprah's administration! Full Story: http://www.eonline.com/news/905074/oprah-winfrey-intrigued-by-2020-presidential-run-gayle-king-says Watch Live from E! here: http://bit.ly/2vGuD5g Subscribe: http://bit.ly/enewssub About E! News: Jason Kennedy and the rest of the E!